Investigation and Results
Notification of Rabies Case
On January 27, 2025, CDC was notified of possible rabies virus infection in a kidney transplant recipient (Figure). After CDC confirmed diagnosis, jurisdictional health departments and CDC conducted an investigation to determine the source of the infection and to identify other persons at risk. This activity was reviewed by CDC, deemed not research, and was conducted consistent with applicable federal law and CDC policy.*
Kidney Recipient
In December 2024, an adult male Michigan resident received a left kidney transplant from an Idaho donor at an Ohio hospital. Approximately 5 weeks later, the recipient experienced tremors, lower extremity weakness, confusion, and urinary incontinence. Seven days after symptom onset, he was hospitalized with fever, hydrophobia, dysphagia, and autonomic instability. On hospital day 2, he required invasive mechanical ventilation. On hospital day 4, clinicians consulted the Ohio Department of Health and CDC because the recipient’s signs and symptoms were compatible with rabies. The Donor Risk Assessment Interview (DRAI) questionnaire reported that the donor had received a skunk scratch. The kidney recipient’s saliva, nuchal skin biopsy, serum, and cerebrospinal fluid samples, collected on hospital days 3–6, were sent to CDC for rabies testing. On hospital day 7, the recipient died; postmortem brain tissue samples were sent to CDC. Rabies virus RNA was detected in saliva, nuchal skin, and brain tissue samples. Rabies virus immunoglobulin (Ig) M, IgG, and neutralizing antibodies were detected in serum. Viral characterization was consistent with the silver-haired bat (Lasionycteris noctivagans) rabies virus variant. Michigan public health officials interviewed the kidney recipient’s family; no animal exposures were reported.
Idaho Organ Donor
After rabies was suspected, the Idaho Department of Health and Welfare, the local public health district, and CDC investigated the Idaho donor as the possible infection source. Interviews with the family added details not included in the DRAI questionnaire. In late October 2024, a skunk approached the donor as he held a kitten in an outbuilding on his rural property. During an encounter that rendered the skunk unconscious, the donor sustained a shin scratch that bled, but he did not think he had been bitten. According to the family, the donor attributed the skunk’s behavior to predatory aggression toward the kitten.
A member of the donor’s household reported that approximately 5 weeks later, in early December, the donor was confused, had difficulty swallowing and walking, experienced hallucinations, and had a stiff neck. Two days after symptom onset, he was found unresponsive at home after presumed cardiac arrest. He was resuscitated and hospitalized but never regained consciousness. He was declared brain dead and removed from life support on hospital day 5. Left kidney, heart, lungs, and both corneas were recovered.
After rabies was suspected in the kidney recipient, stored serum that had been collected from the donor on his third hospital day was tested and determined to be negative for rabies virus antibody. A multiweek laboratory traceback investigation identified right and left kidney biopsy samples. CDC detected rabies virus RNA consistent with a silver-haired bat rabies virus variant in a biopsy sample of the right kidney, suggesting organ-derived transmission. The left kidney biopsy sample had insufficient tissue for testing.
Donor Corneal Tissues and Tissue Recipients
Four ocular grafts were prepared from recovered corneas. Three patients, one each from California, Idaho, and New Mexico, received grafts in December 2024 and January 2025. While investigation of the donor’s rabies status was ongoing, the cornea recipients underwent precautionary graft removal and received PEP. They remained asymptomatic. A planned transplantation of the fourth corneal graft to a Missouri patient was cancelled. CDC detected rabies virus RNA consistent with a silver-haired bat rabies virus variant in one previously implanted corneal graft.
Donor Heart and Lungs
The heart and lungs of the donor were not transplanted but were used in training procedures at a Maryland medical research facility. By the time of the public health investigation, no specimens were available for testing.
